An overview of our focus sessions can be found below. For your convenience you can also download the detailed programme which contains all speakers including focus and parallel sessions.
13:20h – 14:05h
RNA: from fundamental insights to therapeutic applications
Roy van der Meel (TUE)
Wim Velema (RU), Pieter Vader (UUMC)
COVID-19 mRNA vaccine development has demonstrated RNA therapeutics’ remarkable potential. This has been made possible by ground-breaking discoveries related to RNA structure, function, and immunogenicity. At the same time, the development of lipid nanoparticle technology has facilitated the clinical translation of RNA for therapeutic applications. Apart from the use of RNA as therapeutics, cellular RNAs can themselves be targeted with next generation drugs to treat currently ‘undruggable’ diseases. Exciting discoveries of the function and structure of cellular RNA driven by the chemical sciences are accelerating the development of small-molecule RNA modulators. This session will feature examples of state-of-the-art developments regarding fundamental insights in determining RNA structures and innovative nanotechnologies enabling RNA therapy.
Dutch user organisation for accelerator-based light source: Kick-off
Elias Vlieg (RU)
F. Martinez-Criado (ESRF), Moniek Tromp (RUG),
Britta Redlich (RU)
Synchrotron and Free Electron Lasers provide unique tools to characterise the structure, electronics and behaviour of matter at the atomic and molecular level. Using photons, the position and motion of atoms in condensed and living matter can be followed, and the structure of matter in all its complexity can be revealed, from buried interfaces to electronic transitions to fast structural changes in magnetic materials and proteins. Dutch synchrotron and free electron laser facilities are at ESRF and FELIX in Nijmegen. The closure of the Dutch Belgian Beamline, has put pressure on the availability of advanced X-ray scattering and spectroscopy techniques for the Dutch science community. The Netherlands is however still member of the ESRF. In this focus session we want to (i) demonstrate the different options for access to these techniques at ESRF and elsewhere, (ii) demonstrate the new exciting possibilities of the upgraded ESRF with novel impact in a range of (different) fields, (iii) discuss ways to strengthen the Dutch user community and its competitiveness for experiment time at international accelerator-based light sources (synchrotrons and FELs) by introducing the new User organisation DUALiS, (iv) discuss national large scale research facility initiatives towards a Dutch Analytical Platform.
Water-based dynamic covalent chemistries: molecules, techniques, materials
Julieta Paez (UT), Rienk Eelkema (TUD)
Sophie Beeren (TU Denmark), Hagan Bayley (Univ. of Oxford), Rienk Eelkma (TUD)
Dynamic covalent chemistry (DCC) is attracting increasing attention, offering an interesting alternative to the traditional approaches based on ‘static covalent” and ‘dynamic non-covalent’ bonding. DCC is applied in several research fields of chemistry, for example, for the synthesis of small bioactive compounds and porous materials, for controlled delivery of therapeutics, for fabrication of re-processable polymeric networks with a circular economy perspective, for adaptable biomaterials for healthcare, and in systems chemistry. Thereby, the development of novel DCCs that carry out under mild aqueous conditions is of particular interest to expand the DCC toolkit towards environmentally friendly and biological applications, both at the molecular and materials levels. In this focus session, recent advances in the area of water-borne DCC will be highlighted, spanning from fundamental understanding of new DCCs within combinatorial chemistry, through novel single-molecule techniques for characterizing DCCs under close-to-physiological conditions, up to the use of DCCs for molecular engineering of responsive materials for healthcare applications. The aim of this focus session is to demonstrate new opportunities offered by DCCs and to favor fruitful discussion among members of diverse communities, ultimately leading to the crossover of DCC between research areas of chemistry.
Sensing catalytic reactions with light: chemistry meets physics
Esther Alarcon Llado (AMOLF), Eline Hutter (UU)
tbd, Atsushi Urakawa (TUD), Charuseela
Ramanan (VU), Freddy Rabouw (UU), Andrea Baldi (VU)
Catalysts have the potential to drastically lower the temperature needed for chemical reactions, and hence contribute to a greener industry. However, the selectivity of catalytic reactions is a major problem resulting in lots of waste. This session focusses on the combination of physics and chemistry to provide spectroscopic fingerprints of reactive species in chemical reactions as they proceed in space and time. Prof. Redlich will present on catalytic processes studied in the gas phase with free-electron laser infrared spectroscopy. Prof. Urakawa will present how operando spectroscopy can be used to develop novel heterogeneous catalysts with reduced energy usage. Dr. Ramanan will give a talk on the use of light instead of heat to drive chemical reactions, and photophysics of such reactions. Dr. Andrea Baldi will present on super-resolution imaging of catalytic reactions. Finally, dr. Rabouw will give a presentation on local temperature sensing of catalytic reactions using temperature-dependent photoluminescence characteristics of lanthanides. Hence, this session with 5 pitches followed by discussion brings together a broad range of expertise, with a diverse line-up of excellent speakers who will make a highly motivating and dynamic session. This session will foster national collaborations between physicists and chemists on improving catalytic reaction to reduce the industrial energy footprint.
Sensing and digitalization for a sustainable chemical industry
Henk-Jan van Manen (Nouryon)
Jeroen Jansen (RU), Martijn Fransen (Malvern
Panalytical & MinacNed)
The transformation towards Smart industry or Industry4.0 goes hand-in-hand with the collection of a large number of different parameter, both chemical as well as physical. This wealth of data can be exploited for various aims that go beyond the purpose(s) that they were originally collected for and might for example be used the build actionable models for sustainability parameters as well. Another avenue is to become more predictive about sample quality as a result of instrument performance. This sessions will show examples of how such models are constructed and what chemical and mechanistic input is needed in order to end up with useful models. It will also address some fundamental questions about the data and models, such as: how can we trust the sensor data and the models that originate from them? And where lies ownership or responsibility for the data and models?